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Is Nyquil Addictive? Signs and Symptoms of Abuse

Medicine nyquil medication addiction side effectsNyquil is an over-the-counter drug used to treat symptoms caused by allergies, the common cold, the flu, and breathing illnesses like bronchitis and sinusitis. It contains three active ingredients:

  • Acetaminophen – A non-aspirin fever reducer and pain reliever
  • Dextromethorphan – A cough suppressant that alters part of the brain and thus reduces cough
  • Doxylamine succinate – An antihistamine that relieves runny nose, sneezing, itchy eyes, itchy throat and nose, and watery eyes

Do not use Nyquil to treat ongoing coughs from smoking, long-term breathing problems or asthma. Like other over-the-counter drugs, continuous use of Nyquil may cause serious side effects, dependence and, in some cases, withdrawal symptoms.


How to Take Nyquil

Ensure that you read and follow all instructions on the packaging label. Use it as directed by your pharmacist or doctor.

If you are taking Nyquil in liquid form, measure the dose using the given measuring spoon. Nyquil is also available as extended-release capsules.

The dosage recommendation you get from your doctor is based on your response to treatment, age, and medical condition. Avoid taking it more than prescribed, longer than prescribed, or increasing your dose. Improper use may lead to abuse and harm like brain damage or seizure.

If your condition continues for more than one week or worsens, let your doctor know as it may not be the right medication for you.



One of the ingredients found in Nyquil is acetaminophen. If you consume too much acetaminophen, it can lead to liver disease. If you have liver problems, take only small amounts of acetaminophen. Children should also take fewer amounts. Consult with your doctor on how much acetaminophen you should take.

Do not combine Nyquil with other drugs unless under your doctor’s orders. Since acetaminophen is found in many cough and cold medications, check all the labels on your medicine. If you find that it is present, ask your doctor or pharmacist for guidance.


Minor Side Effects of Nyquil

Prolonged use of Nyquil can have adverse effects on your health. However, many people using this prescription do not experience serious side effects. Some of the side effects include:

  • Dizziness
  • Dry mouth, throat or nose
  • Blurred vision
  • Constipation
  • Upset stomach
  • Nervousness
  • Nausea

Doctors recommend this medication if they feel that the benefits outweigh the risks of side effects. If you experience the above side effects, talk with your doctor.


Serious Side Effects of Nyquil

In some cases, you may experience the following more serious side effects:

  • Trouble urinating
  • Shaking
  • Mood changes
  • Confusion
  • Hallucinations
  • Irregular heartbeat
  • Seizure

Tell your doctor so that they may take appropriate action. Some patients report significant allergic reactions when they take Nyquil. Seek medical attention if you experience allergic reactions like:

  • Breathing trouble
  • Rashes
  • Swelling or itching of the throat, tongue or face
  • Severe dizziness


Precautions to Consider

The following are some precautions you should take by speaking with your doctor before taking this medication:

  • Existing health problems: High blood pressure, seizures, kidney problems, overactive thyroid, asthma, diabetes, heart problems, glaucoma, constipation, etc.
  • Allergies: Any form of allergies
  • Certain diseases: Nyquil contains aspartame, alcohol or sugar, so if you have liver disease, phenylketonuria, alcohol dependence, diabetes or a condition that requires you to limit the use of these substances, proceed with caution and seek your doctor’s advice
  • Older individuals: Older people have a higher sensitivity to Nyquil; low blood pressure, constipation, dizziness and drowsiness increase the chances of falling
  • Surgical procedures: Advise your doctor before any intensive surgeries
  • Avoid operating heavy machinery: May cause blurred vision and drowsiness, so do not drive, operate machinery, drink alcohol, or engage in something that requires alertness
  • Avoid breastfeeding: Nyquil can pass into breast milk and lead to undesirable effects in an infant


Interaction With Other Drugs

Drug interaction can alter how your prescription works, and in some cases, it may increase the risk of significant side effects. Ensure that you record all your medications and show them to your doctor. Do not stop or change the dosage without your doctor’s approval.

Some MAO inhibitors lead to serious drug interaction when taken alongside Nyquil. They include:

  • Methylene blue
  • Selegiline
  • Isocarboxazid
  • Moclobemide
  • Procarbazine
  • Safinamide
  • Phenelzine
  • Rasagiline
  • Tranylcypromine
  • Alcohol
  • Marijuana
  • Sleeping and anxiety drugs
  • Muscle relaxants
  • Antihistamines
  • Opioids like codeine and hydrocodone
  • Ketoconazole
  • Rolapitant

Nyquil contains medications found in other products, so using such products alongside Nyquil may increase the overall side effects. Nyquil may also interfere with your lab tests, leading to false results. Before undertaking a lab test, make sure your doctor knows that you use Nyquil.


Nyquil Signs and Symptoms of Abuse

The consistent use of Nyquil over a long period may lead to dependency and addiction, especially if you are using it against to your doctor’s advice. Addiction cases may result when you use any drug more often than is recommended to achieve the desired effect.


Signs and Symptoms of Abuse

When this medication is used alone, the chances of getting Nyquil addiction are low. However, when combined with other drugs such as alcohol and marijuana, you may experience dangerous health complications such as:

  • Confusion
  • High blood pressure
  • Impaired motor control
  • Seizures
  • Hallucinations

Individuals who have Nyquil use disorder can develop liver and kidney damage. In some cases, they also experience memory problems. By the time you realize that you are addicted to Nyquil, it may be much more difficult to quit using it. The sudden stop of Nyquil use might lead to significant withdrawal symptoms, so before stopping, seek the advice of your doctor.


Withdrawal Symptoms

Withdrawal symptoms occur within a few hours after stopping, and they peak within three days. Some common Nyquil withdrawal symptoms include:

  • Insomnia
  • Seizures
  • Restlessness
  • Tremors
  • Vomiting and stomach cramps
  • Cold flashes
  • Weight loss
  • Depression
  • Anxiety
  • Cravings

The good news is that Nyquil addiction is treatable if you follow all the recommended detox procedures.



There is always a risk of an overdose when you use Nyquil other than prescribed by your doctor. The following symptoms are predominant in an individual who has overdosed:

  • Nausea
  • Seizures
  • Vomiting
  • Dark urine
  • Loss of appetite
  • Yellowing eyes or skin
  • Sweating
  • Hallucinations
  • Abdominal pain
  • Flushing
  • Extreme tiredness
  • Confusion
  • Agitation

Children may be excited at first, followed by loss of consciousness, drowsiness, seizures and coordination loss. If you come across an individual who has overdosed, call 911 or a poison control center right away.

Often, addiction leads to an overdose, knowingly or unknowingly. To prevent future cases of Nyquil overdose and other health complications, seek medical rehabilitation to help you quit using the drug. A rehabilitation facility like Granite Recovery Centers can guide you on your road to recovery.


Granite Recovery Centers

Your recovery journey starts at Granite Recovery Centers. We’ve been helping adults with substance use disorder and mental health issues for over 10 years.

Our full continuum of care features primary residential treatment, sober living, medical detox, intensive outpatient counseling, and much more. Our active and growing alumni community is evidence of our success, so you can trust us with your health. Granite Recovery Centers provides medical detoxification for people who do not need immediate medical intervention, are not a danger to themselves, and are capable of self-evacuation in the event of an emergency.


Our Facilities

Granite Recovery Centers provides drug rehabilitation programs to help individuals who want to leave substance abuse and dependence behind them. Seek our services today if you need help to overcome substance use disorder. The journey may be difficult, but it is worth the effort.



Although it is rare to become addicted to Nyquil, there is always a chance when you use it with other drugs like alcohol or marijuana. Do not take Nyquil other than prescribed by your pharmacist or doctor. If you endure significant withdrawal symptoms after stopping its use, seek the intervention of your doctor.